Chicken Alfredo Casserole

4.7
(49)
43 Reviews
10 Photos

A nice play on chicken Alfredo, easy to make and yummy to eat. My entire family enjoys it, even my 1-year-old!

Submitted by krissymarie
Updated on November 26, 2023
Tested by
Allrecipes Test Kitchen
Tested by Allrecipes Test Kitchen
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Close up on a casserole dish of chicken alfredo casserole.
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Prep Time:
15 mins
Cook Time:
45 mins
Total Time:
1 hr
Servings:
6
Yield:
6 servings
Jump to Nutrition Facts

Ingredients

  • 3 skinless, boneless chicken breast halves

  • 1 (8 ounce) package penne pasta

  • ½ (16 ounce) jar Alfredo sauce

  • 1 ½ cups shredded mozzarella cheese, divided

  • ¼ cup milk

  • 1 tablespoon onion powder

  • 1 tablespoon garlic powder

  • 1 cup shredded Cheddar cheese

Directions

  1. Preheat the oven to 350 degrees F (175 degrees C).

  2. Place chicken into a pot and cover with water. Bring to a boil over high heat; reduce heat and simmer until no longer pink in the centers and juices run clear, about 15 minutes.

  3. At the same time, bring a large pot of lightly salted water to a boil. Add penne and cook, stirring occasionally, until tender yet firm to the bite, about 11 minutes. Drain.

  4. Drain cooked chicken and cut into bite-size pieces.

    Overhead of chicken breasts cooking in a skillet with water with cut up chicken on a plate to the side.

    Dotdash Meredith Food Studios

  5. Place chicken, noodles, Alfredo sauce, 1/2 mozzarella cheese, milk, onion powder, and garlic powder in a large bowl and mix well.

    Overhead of noodles, chicken, and an unmixed alfredo mixture in bowls.

    Dotdash Meredith Food Studios
    Overhead of chicken Alfredo casserole ingredients mixed together in a bowl with a baking dish off to the side.

    Dotdash Meredith Food Studios

  6. Pour into a 1 1/2-quart casserole dish. Layer remaining mozzarella cheese and Cheddar cheese on top.

    Overhead of an uncooked chicken Alfredo casserole in a baking dish covered in cheese.

    Dotdash Meredith Food Studios

  7. Bake in the preheated oven until melted and bubbly, about 25 minutes.

Cook’s Note

You can use any medium pasta noodles that you prefer, such as ziti, large elbow, etc.

If using the second half of a jar of Alfredo sauce, swirl the milk in the jar to get all of it out.

Nutrition Facts (per serving)

468 Calories
24g Fat
32g Carbs
31g Protein
Nutrition Facts
Servings Per Recipe 6
Calories 468
% Daily Value *
Total Fat 24g 31%
Saturated Fat 12g 59%
Cholesterol 86mg 29%
Sodium 693mg 30%
Total Carbohydrate 32g 12%
Dietary Fiber 2g 5%
Total Sugars 4g
Protein 31g 62%
Vitamin C 0mg 0%
Calcium 387mg 30%
Iron 2mg 9%
Potassium 250mg 5%

* Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

** Nutrient information is not available for all ingredients. Amount is based on available nutrient data.

(-) Information is not currently available for this nutrient. If you are following a medically restrictive diet, please consult your doctor or registered dietitian before preparing this recipe for personal consumption.

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